Aβ42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila
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Aβ42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila
Aggregation of the amyloid-beta-42 (Abeta42) peptide in the brain parenchyma is a pathological hallmark of Alzheimer's disease (AD), and the prevention of Abeta aggregation has been proposed as a therapeutic intervention in AD. However, recent reports indicate that Abeta can form several different prefibrillar and fibrillar aggregates and that each aggregate may confer different pathogenic effe...
متن کاملAbeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila
Aggregation of the amyloid-b-42 (Ab42) peptide in the brain parenchyma is a pathological hallmark of Alzheimer’s disease (AD), and the prevention of Ab aggregation has been proposed as a therapeutic intervention in AD. However, recent reports indicate that Ab can form several different prefibrillar and fibrillar aggregates and that each aggregate may confer different pathogenic effects, suggest...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2008
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0001703